Polynucleotide-treatments

DIYAH AESTHETICS · MARYLEBONE NW1 & RICHMOND TW10

Polynucleotide Treatments in Marylebone and Richmond

Three advanced polynucleotide treatments for deep skin regeneration, tissue repair and lasting rejuvenation. Delivered by a GDC registered practitioner with over 10 years of clinical experience.

Specialist Polynucleotide Treatments at Diyah Aesthetics

Polynucleotides are a class of injectable treatments derived from highly purified DNA strands. They work at a cellular level to stimulate your skin’s own regenerative processes: increasing fibroblast activity, boosting natural collagen and elastin production, improving tissue hydration and accelerating the repair of damaged cells. This is not about adding volume. It is about restoring the biological health of your skin.


At Diyah Aesthetics, Mahtab offers three leading polynucleotide treatments: Plinest, Nucleofill and Vitaran. Each has a distinct formulation and mechanism, making the right choice dependent on your individual skin assessment. During your free consultation, Mahtab will evaluate your skin and recommend the most appropriate approach.


PDRN-based polynucleotide that stimulates tissue regeneration and collagen synthesis. Proven for skin repair, hydration and overall quality improvement.


High-concentration polynucleotide gel delivering intense hydration and cellular regeneration. Restores elasticity and deeply revitalises compromised skin.


Polynucleotide and hyaluronic acid combination for simultaneous regeneration and volumetric hydration. Targets multiple concerns in a single treatment.

Plinest

Plinest uses PDRN (polydeoxyribonucleotide), a highly purified compound derived from salmon DNA that is extensively researched and clinically validated. PDRN activates the A2A adenosine receptor pathway, which directly stimulates tissue regeneration, triggers fibroblast proliferation and promotes the natural production of collagen and extracellular matrix proteins.


The result is a measurable improvement in skin quality, texture and hydration that builds progressively over a course of treatments. Plinest is particularly effective for clients with dull, tired or photo-aged skin seeking genuine cellular renewal rather than surface-level improvement.


PDRN activates the A2A receptor pathway to directly stimulate skin cell repair and renewal.


Triggers fibroblast proliferation for a sustained increase in natural collagen and elastin synthesis.


Improves the skin’s capacity to retain moisture at a structural level for lasting suppleness.


Measurably improves overall texture, tone and luminosity through genuine biological rejuvenation.

Nucleofill

Nucleofill is a high-concentration polynucleotide gel that delivers an intensive regenerative effect for clients with more significant skin concerns. Its higher polynucleotide density means a stronger stimulation of fibroblast activity and a more pronounced improvement in skin elasticity, firmness and overall vitality.


Nucleofill is particularly suited to clients experiencing more advanced signs of skin ageing: loss of firmness, deep dehydration, reduced elasticity and a general decline in skin vitality that lighter treatments have not fully addressed.


Greater polynucleotide density delivers stronger fibroblast stimulation and more pronounced regenerative results.


Targets loss of skin firmness and elasticity with intensive bio-regeneration at a cellular level.


Restores vitality to compromised or chronically dehydrated skin that other treatments have not resolved.


Results build across a course of treatments, with cumulative improvement in texture, tone and resilience.

Vitaran

Vitaran combines polynucleotides with hyaluronic acid in a single formulation, creating a dual-action treatment that addresses both cellular regeneration and volumetric hydration simultaneously. The polynucleotide component triggers the skin’s own repair and collagen-building processes, while the hyaluronic acid provides immediate structural hydration and skin plumping.


Vitaran is an excellent choice for clients who want the regenerative benefits of polynucleotides alongside the visible, immediate improvement in skin texture and hydration that HA delivers. It is also a strong option for those new to polynucleotide treatments who want a comprehensive result from a single product.


Combines polynucleotide regeneration with HA hydration for simultaneous biological and structural improvement.


The HA component delivers visible skin plumping and texture improvement from the first session.


Polynucleotides continue stimulating collagen and tissue repair progressively after each treatment.


Suitable for a range of concerns and skin types. An ideal starting point for polynucleotide treatment.

Which Polynucleotide Treatment Is Right for You?

A guide to the key differences. Mahtab will confirm the right choice at your free consultation.

Not Sure Which Treatment Is Right for You?

Book Free Consultation a free 15-minute consultation. Mahtab will assess your skin and recommend the right polynucleotide treatment for your goals.









Polynucleotide Treatment Prices

Transparent pricing. No hidden costs, no pressure. All prices apply across Plinest, Nucleofill and Vitaran.

Why Choose Diyah Aesthetics

Mahtab holds GDC registration, a level of clinical governance most aesthetics practitioners do not have. Your safety underpins every treatment decision.


Ten years of clinical experience in dental medicine provides an exceptional understanding of facial anatomy, tissue layers and precise injection placement.


Access to Plinest, Nucleofill and Vitaran means the right polynucleotide is chosen for your skin and goals, not simply the most available option.


Every plan is tailored to your skin assessment and timeline. No standard protocols or generic approaches.

What to Expect

Mahtab assesses your skin, discusses your concerns and recommends the right polynucleotide formulation for your goals.


Skin is cleansed and a topical numbing cream applied for comfort before treatment begins.


Precise microinjections across the face and neck. Sessions take 20 to 30 minutes from start to finish.


Small injection points fade within 24 to 48 hours. You can return to your normal routine the same day.


Some immediate improvement in hydration. Regenerative results build progressively over four to eight weeks.

What Our Clients Say

21 five star reviews on Google


"The level of work, attention to detail and effort Mahtab puts into her treatments has been incredible. Professional, knowledgeable and genuinely cares about getting results."


Verified Google Review


"I was nervous about injectables but Mahtab explained everything so clearly. My skin looks hydrated and refreshed with no downtime at all. One of the best treatments I have had."


Verified Google Review


"Mahtab made me feel completely at ease from the start. The results were better than I expected. Natural, glowing and zero downtime. I will absolutely be coming back."


Verified Google Review

Polynucleotide FAQs






Start Your Skin Regeneration Journey

Book your free 15-minute consultation at our Marylebone or Richmond clinic. Mahtab will assess your skin and recommend the right polynucleotide treatment for your goals.







Luxury aesthetic treatments in Richmond and Marylebone, delivered with precision, discretion and clinical expertise.



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