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Can You Have Anti-Wrinkle Injections and Polynucleotides Together?


By Mary Basiadima, 6 May 2025


As aesthetic become more advanced, many people are exploring ways to for enhanced results. One question that often comes up is: can you have anti-wrinkle injections and polynucleotides together?


The short answer is — yes, you can, and when done correctly, combining these treatments can offer a synergy for smoother, healthier, more rejuvenated skin. Let’s take a closer look at how they work individually and why combining them might be the best approach for your skin goals.

What Are Anti-Wrinkle Injections?

are one of the most popular non-surgical for reducing fine lines and . They work by temporarily the muscles for lines, particularly around the forehead, eyes, and mouth.


By muscle activity, anti-wrinkle smooth out existing lines and help prevent new ones from forming. The result is a fresher, more appearance, with treatments typically lasting three to four months before a top-up is needed.

What Are Polynucleotides?

are an innovation in regenerative aesthetics. Derived from highly Salmon DNA fragments, they work differently from or anti-wrinkle injections. the skin’s repair processes, collagen and elastin production and skin at a cellular level.


Rather than simply addressing wrinkles or volume loss, target skin health more broadly, hydration, texture, and elasticity. This makes them ideal for anyone looking for a natural, regenerative approach to skin ageing.

Can You Have Anti-Wrinkle Injections and Polynucleotides Together?

. In fact, anti-wrinkle and can be a highly strategy for facial rejuvenation.


Used together, these tackle ageing on fronts: muscle activity to smooth wrinkles, while encouraging the skin to heal and regenerate naturally. The result is not only fewer lines but also healthier, firmer, and more skin.


Many at our Clinics choose to combine these during the same visit or space them a few weeks apart, on skin needs and goals.

Are There Benefits to Combining the Two Treatments?

Yes — can enhanced, more natural-looking results compared to using either treatment alone. Some key include:


By both the and the skin itself, you create a multi-dimensional approach to that’s difficult to achieve with a single treatment alone.

Is It Safe to Combine Anti-Wrinkle Injections and Polynucleotides?

Yes, when by an experienced practitioner, it is entirely safe to these treatments. At our Clinics, all procedures are out by trained professionals who assess your skin and plans to suit your individual needs.


It’s important to have a thorough consultation to determine the best timing and strategy for you. Sometimes, treatments may be done during the same appointment, while in other cases, a short gap between might be recommended to and .

How Soon Will I See Results?

Anti-wrinkle injections: Typically, become visible within 3 to 7 days, with full effects at around two weeks.


Polynucleotides: in skin develop over weeks, as collagen and elastin production increase.


When combined, you can expect to see both immediate improvements in and enhancements in skin texture and over time, a refreshed, that continues to improve.

Combining Treatments for Optimal Skin Health

So, can you have anti-wrinkle injections and polynucleotides together? The answer is yes, and the can deliver powerful, natural-looking . By both muscle movement and skin health, you smoother, firmer, and more radiant skin that lasts.

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The best order often depends on your skin goals and what you’re hoping to . In many cases, anti-wrinkle injections are first to soften lines caused by muscle movement. Polynucleotides can then be to improve overall skin quality, hydration, firmness, and collagen production. However, some practitioners may with polynucleotides to prepare and the skin before relaxing the muscles. Our practitioners will assess your skin during and develop a plan tailored to your needs for optimal results.


After anti-wrinkle injections, it’s best to avoid using strong or irritating skincare products for at least 24 to 48 hours. This exfoliants, retinol, alpha hydroxy acids (AHAs), beta acids (BHAs), and . These products can sensitivity and at the sites. Instead, stick to gentle, hydrating and always follow your practitioner’s instructions to ensure the best possible outcome.


After a polynucleotide treatment, it’s to avoid certain activities to allow your skin to heal and maximise results. For at least 24 to 48 hours, avoid exercise, hot baths or saunas, and applying makeup over the treated area. You should also stay out of direct sunlight and always use a SPF if you need to go . Gentle skincare is recommended, and it’s best to avoid exfoliants, active ingredients, or harsh until your it’s safe. Proper aftercare helps ensure your skin fully from the regenerative of polynucleotides.













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